What can we learn about amphiphile-membrane interaction from model lipid membranes?

FANANI, MARIA LAURA; NOCELLI, NATALIA; DE LAS MERCEDES ZULUETA DÍAZ, YENISLEIDY

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ELSEVIER SCIENCE BV

Año: 2021

0005-2736

urface-active amphiphiles find applications in a wide range of areas of industry such as agrochemicals, personal care, or pharmaceuticals. In many of these applications interaction with cell membranes is a key factor for achieving their purpose. How amphiphiles interact with lipid membranes? What are their bases for membrane specificity? What are the biophysical properties of membranes that are susceptible to be modulated by amphiphilic membrane-effectors? What aspects of this interaction are relevant for performing their function? In our work on membrane biophysics over years, questions like those have arisen and now we are sharing some of our findings and discussing them in this revision work. It does not aim to provide a comprehensive list of the mode of action of amphiphiles of biological interest but to help in the understanding of them.