Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

MARCHESE, N; ARTUR DE LA VILLARMOIS, E; BASMADJIAN, OM; PEREZ, MARIELA FERNANDA; BAIARDI, G; BREGONZIO C

SPRINGER

Lugar: Berlin; Año: 2015

ationale.Angiotensin II, by activation of its brain AT1 receptors (AT1-R), plays an active role as neuromodulator in DA transmission.DA is involved in cognitive processes and brain related areas connectivity. Amphetamine (Amph) by its mimetic activity over DA neurotransmission elicits altered responsesafter long-term withdrawal periods, when animals are re-exposed to the drug. AT1-R play an active role in the development of dopaminergic and behavioral sensitization induced by Amph.Objective.Assessthe acute and long-term Amph-induced alterationsin long-term memoryandin cellular related eventsandevaluatethe AT1-R involvement in these events.Methods.Male Wistar rats (250-300g). Acute effects: Amph (0.5/2.5 mg/kg i.p.) was administered after post-training inthe inhibitory avoidance (IA) response. The AT1-R blocker Losartan was administered i.c.v. before a single dose of Amph (0.5mg/kg i.p.). Long-term effects:The AT1-R blocker Candesartan (3mg/kg p.o.) was administered for 5 days followed