IMPACT OF CONTEXTUAL CUES IN THE EXPRESSION OF THE MEMORY ASSOCIATED WITH DIAZEPAM WITHDRAWAL: INVOLVEMENT OF HIPPOCAMPAL PKMæ IN VIVO AND ARC EXPRESSION AND LTP IN VITRO

CAROLINA MONTI; LAURA GABACH; MARIELA F. PÉREZ.; OSCAR A RAMIREZ

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2012 vol. 36 p. 3118 - 3118

0953-816X

ippocampal synaptic plasticity has been related to learning and adaptive processes developed during chronic drug administration, suggesting the existence of a common neurobiological mechanism mediating drug addiction and memory. Moreover, Protein Kinase M Zeta (PKMæ) is critical for the maintenance of hippocampal long-term potentiation (LTP) and spatial conditioned long-term memories. Also, a link between activity-regulated cytoskeletal-associated protein (Arc), PKMæ and LTP has been proposed. Our previous results demonstrated that re-exposure to the withdrawal environment was able to evoke the memory acquired when the anxiety measured as a diazepam withdrawal sign was experienced. In the present work we evaluated if the memory associated with diazepam withdrawal could be affected by changes in the contextual cues presented during withdrawal and by intrahippoca