HIPPOCAMPAL SYNAPTIC PLASTICITY IN MICE DEVOID OF CELLULAR PRION PROTEIN

MAGLIO LE; MARIELA F. PÉREZ.; MARTINS VR, BRENTANI RR, RAMIREZ OA

MOLECULAR BRAIN RESEARCH

ELSEVIER

Año: 2004 vol. 131 p. 58 - 58

0169-328X

he cellular prion protein plays a role in the etiology of transmissible and inherited spongiform encephalopathies. However, the physiological role of the cellular prion protein is still under debate. Results regarding the synaptic transmission using the same strain of animals where the cellular prion protein gene was ablated are controversial, and need further investigation. In this work, we have studied the hippocampal synaptic transmission in mice devoid of normal cellular prion protein, and have shown that these animals present an increased excitability in this area by the lower threshold (20 Hz) to generate long-term potentiation (LTP) in hippocampal dentate gyrus when compared to wild-type animals. The mice devoid of normal cellular prion protein are also more sensitive to the blocking effects of dizocilpine and 2-amino-5-phosphonopentanoic acid on the hippocampal long-term potentiation generation. In situ hydridization experiments demonstrated overexpression of the mRNAs for the