NMDA-NR1 AND -NR2B SUBUNITS mRNA EXPRESSION IN THE HIPPOCAMPUS OF RATS TOLERANT TO DIAZEPAM.

MARIELA F. PÉREZ.; ROMINA ALMIRON ; OSCAR A RAMIREZ

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Año: 2003 vol. 144 p. 119 - 119

0166-4328

font size="1" face="Times New Roman"> The development of tolerance to the hypolocomotor effects of Diazepam (DZ) is thought to be a contingent or learning phenomenon. In previous reports, we demonstrated a positive correlation between the development of tolerance to the sedative effects of DZ and hippocampal synaptic plasticity. Furthermore, previous exposure to the drug administration context blocks both the tolerance to sedative effects of DZ and the increased hippocampal plasticity. The results of the present investigation show that the development of tolerance to hypolocomotor action of DZ (5 mg/kg/day) for 4 days results in a significant increase in the hybridization signals for mRNA for N