Reduced vasopressin receptors activation mediates the anti-depressant effects of fluoxetine and venlafaxine in bulbectomy model of depression

PORETTI, MARIA BELÉN; SAWANT, RAHUL; RASK-ANDERSEN, MATHIAS; FIOL DE CUNEO, MARTA; SCHIÖTH, HELGI; PÉREZ, MARIELA F; VALERIA P CARLINI

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2015 vol. 233 p. 1077 - 1077

0033-3158

ationale: In response to stress, corticotropin releasing hormone (CRH) andvasopressin (AVP) are released from the hypothalamus, activate their receptors(CRHR1, CRHR2 or AVPr1b), and synergistically act to induce adrenocorticotropichormone (ACTH) release from the anterior pituitary. Overstimulation of this system has been frequently associated with major depression states.Objective: to assess the role of AVP and CRH receptors in fluoxetine and venlafaxineeffects on the expression of depression-related behavior.Methods: In an animal model of depression (olfactory bulbectomy in mice, OB) weevaluated the effects of fluoxetine or venlafaxine (both 10 mg/kg/day) chronicadministration on depression-related behavior in the tail suspension test. Plasma levels of AVP, CRH and ACTH were determined as well as participation of their receptors in the expression of depression related-behavior and gene expression of AVP and CRHreceptors (AVPr1b, CRHR1 and CRHR2) in the pituitary gland.Results: The ex