Neopterin acts as an endogenous cognitive enhancer

KARINA GHISONI; FILIPE CARVALHO MATHEUS; PAULO ALEXANDRE DE OLIVEIRA; RUI PREDIGER; LAURA GABACH; MARIELA F. PÉREZ; VALERIA P. CARLINI; LUIZ BARBEITO; ADERBAL AGUIAR; LAURENCE LANFUMEY; ALEXANDRA LATINI

BRAIN BEHAVIOR AND IMMUNITY

ACADEMIC PRESS INC ELSEVIER SCIENCE

Lugar: Amsterdam; Año: 2016

0889-1591

eopterin, a byproduct of the tetrahydrobiopterin de novo pathway, is found at increased levels in biological fluids from individuals affected by inflammatory disorders. The role of this pteridine in still not defined, however due to its capacity to increase hemeoxygenase-I content, it was proposed a cytoprotective activity, during cellular stress. Therefore, in order to understand better its effect in in vivo systems, we investigated the effect of neopterin on cognition. To address this, neopterin (0.4 and/or 4 pmol) was injected intracerebroventricularly before or after the acquisition sessions in step-down and fear conditioning tests, respectively, and avoidance or fear memories were, assessed in Swiss and VGV (mice with fully edited isoform of the serotonin receptor subtype 2C) mice, and Wistar rats. The effect of neopterin on memory was also investigated under an inflammatory state induced by intraperitoneal lipopolysaccharide administration (0.33 mg/kg) in IL-10(-/-). It was con