Titanium Dioxide Nanoparticles in sunscreens and skin photodamage. Development, synthesis and characterization of a novel biocompatible alternative based on their in vitro and in vivo study

PEREZ, MF

Journal of Photochemistry and Photobiology.

Elsevier

Año: 2023

2666-4690

itanium dioxide nanoparticles are widely used in cosmetics, especially in sunscreens due to their capacity to absorb UV harmful wavelengths. However, their biocompatibility remains controversial. To the best of our knowledge, this is the first reported photo-toxicity study. In this work, the effect of titanium dioxide nanoparticles under solar-simulated radiation was studied in vitro and in vivo. Cell viability and tissue integrity were affected after exposure to titanium dioxide nanoparticles and light for 6 h, showing signs of significant oxidative stress markers and reduced tissue integrity observed by TEM. In order to avoid these undesired effects, a novel biocompatible alternative was presented based on titanium dioxide nanoparticle functionalization with vitamin B2 through a rapid sol-gel method. None of the photo-toxicity effects were observed with these functionalized nanoparticles.