PEREZ MARIELA FERNANDA
Congresos y reuniones científicas
Título:
DUAL OPPOSING ACTIONS OF NITRIC OXIDE ON MEMBRANE ACTIVITY OF STRIATAL MEDIUM SPINY NEURONS: AN IN VITRO ANALYSIS
Autor/es:
WEST AR, HU X.-T, WHITE FJ AND PEREZ MF
Lugar:
San Diego, USA
Reunión:
Congreso; Society for Neuroscience; 2004
Institución organizadora:
Society for Neuroscience
Resumen:
Ultrastructural studies have shown that nitric oxide synthase (NOS) immunoreactive processes synapse on the dendritic spine shafts of MSNs (Calabresi et al., 1999) known to contain high levels of GC, cGMP, and PKG (Ariano, 1983). Recent electrophysiological studies have demonstrated that nitric oxide (NO) modulates the activity of striatal medium spiny neurons (MSNs) via activation of the guanylyl cyclase (GC)-cGMP second messenger system (Calabresi et al., 1999, West and Grace, 2004). These findings indicate that activation of striatal NOS-containing interneurons may play an important role in integrating motor information and synchronizing the activity of functionally related striatal output pathways. Recent studies showing that NOS markers are decreased in 6-OHDA lesioned animals (De Vente et al., 2000) and post-mortem Parkinsonian brains (Bockelmann et al., 1994) suggest that dysfunctional nitrergic transmission may occur in patients with Parkinson?s disease (PD). Taken together with observations that NO facilitates both tonic and phasic striatal DA neurotransmission in vivo (West et al., 2002a), these studies suggest that agents or treatments designed to augment striatal NOS activity may be useful as antiparkinsonian therapeutics.
