Somuncurins: Bioactive Peptides from the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense

NATALIA L. CANCELARICH; NATALIA WILKE; M. LAURA FANANI; DANIEL C. MOREIRA; LUIS O. PÉREZ; EDER ALVES BARBOSA; ALEXANDRA PLÁCIDO; RENATO SOCODATO; CAMILA C. PORTUGAL; JOÃO B. RELVAS; BEATRIZ G. DE LA TORRE; FERNANDO ALBERICIO; NÉSTOR G. BASSO; JOSÉ R. LEITE; MARIELA M. MARANI

JOURNAL OF NATURAL PRODUCTS

AMER CHEMICAL SOC

Lugar: Washington; Año: 2020

0163-3864

he skin glands of amphibian species hold a majorcomponent of their innate immunity, namely a unique set ofantimicrobial peptides (AMPs). Although most of them have commoncharacteristics, differences in AMP sequences allow a huge repertoire ofbiological activity with varying degrees of efficacy. We present the firststudy of the AMPs from Pleurodema somuncurence (Anura:Leptodactylidae: Leiuperinae). Among the 11 identified maturepeptides, three presented antimicrobial activity. Somuncurin-1(FIIWPLRYRK), somuncurin-2 (FILKRSYPQYY), and thaulin-3(NLVGSLLGGILKK) inhibited Escherichia coli growth. Somuncurin-1 also showed antimicrobial activity against Staphylococcus aureus.Biophysical membrane model studies revealed that this peptide had agreater permeation effect in prokaryotic-like membranes and capacityto restructure liposomes, suggesting fusogenic activity, which couldlead to cell aggregation and disrup