The rheological properties of lipid monolayers modulates the incorporation of L-ascorbic acid alkyl esters

Y. ZULUETA DIAZ; M. MOTTOLA; R. VICO; N. WILKE; M.L. FANANI

LANGMUIR

AMER CHEMICAL SOC

Lugar: Washington; Año: 2016 vol. 32 p. 587 - 587

0743-7463

n this work, we tested the hypothesis that the incorporation of amphiphilic drugs into lipid membranes may beregulated by their rheological properties. For this purpose, two members of the L-ascorbic acid alkyl esters family (ASCn) wereselected, ASC16 and ASC14, which have different rheological properties when organized at the air/water interface. They arelipophilic forms of vitamin C used in topical pharmacological preparations. The effect of the phase state of the host lipidmembranes on ASCn incorporation was explored using Langmuir monolayers. Films of pure lipids with known phase states havebeen selected, showing liquid-expanded, liquid-condensed, and solid phases as well as pure cholesterol films in liquid-orderedstate. We also tested ternary and quaternary mixed films that mimic the properties of cholesterol containing membranes and ofthe stratum corneum. The compressibility and shear properties of those monolayers were assessed in order