The interfacial properties of the peptide polybia-mp1 and its interaction with DPPC are modulated by lateral electrostatic attractions

D. S. ALVARES; M.L.FANANI; J. RUGGERO NETO; N. WILKE

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 1858

0005-2736

!--[if gte mso 9]> Polybia-MP1 (IDWKKLLDAAKQIL-NH2), extractedfrom the Brazilian wasp Polybia paulista,exhibits a broad-spectrum bactericidal activity without being hemolytic andcytotoxic. In the present study, we analyzed the surface properties of thepeptide and its interaction with DPPC in Langmuir monolayers. Polybia-MP1 formedstable monolayers, with lateral areas and surface potential values suggesting amostly a-helical structure oriented near perpendicular to themembrane plane. In DPPC-pept