Interaction of dextran derivatives with lipid monolayers and the consequential modulation of the film properties

C.I.CAMARA; N. WILKE.

CHEMISTRY AND PHYSICS OF LIPIDS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2017 vol. 204 p. 34 - 34

0009-3084

olysaccharides have been associated with various biological functions through their binding to membranes, but their specific role is still under debate. The aim of this work was to study the interaction of cationic and anionic polysaccharides with anionic and zwitterionic monolayers, at different subphase compositions, thus analyzing the influence of electrostatics on the interaction. The consequent effect of the polymer-lipid binding on the film properties was studied, with special interest in monolayer dynamics. The results indicate that electrostatic interactions play an important role in polymer-membrane affinity, and that the polymers formed a sub-layer, which increased the shear viscosity of the interface. The interacting polymer, even when it did not penetrate the lipid film, induced a polymer-like behavior of the monolayer regarding its dynamics: the whole film (polymer + lipid) became very viscous. As a consequence, the dynamic of the membrane was affected, thus inducing chan