Cross-Sensitization Between Cocaine and Acute Restraint Stress is Associated with sensitized Dopamine but not Glutamate Release in the Nucleus Accumbens

GARCIA KELLER C; MARTINEZ SA; ESPARZA A; BOLLATI F; KALIVAS PW; CANCELA LM

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2013

0953-816X

span lang="en" style="font-family: "Arial","sans-serif";">Repeated administration of psychostimulant drugs or stress can elicit a sensitized response to the stimulating and reinforcing properties of the drug. Here we explore the mechanisms in the nucleus accumbens (NAc) whereby an acute restraint stress augments the acute locomotor response to cocaine. This was accomplished by a combination of behavioral pharmacology, microdialysis measures of extracellular dopamine and glutamate, and Western blotting for GluR1 subunit of the AMPA glutamate receptor (AMPAR). A single exposure to restraint stress 3 weeks before testing revealed that enduring locomotor sensitization to cocaine was paralleled by an increase in extracellular dopamine in the core, but not the shell subcompartment of the