IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity

LUCAS SOSA; SEBASTIAN DUPRAZ; LISANDRO LAURINO; FLAVIA BOLLATI; MARIANO BISBAL; ALFREDO CACERES; KARL H PFENNINGER; SANTIAGO QUIROGA

nature publishing group

Año: 2006 vol. 9 p. 993 - 993

How a neuron becomes polarized remains largely unknown. Results obtained with a function-blocking antibody and an siRNA targeting the insulin-like growth factor-1 (IGF-1)receptor suggest that an essential step in the establishment of hippocampal neuronal polarity and the initiation of axonal outgrowth is the activation of the phosphatidylinositol 3-kinase (PI3k)-Cdc42 pathway by the IGF-1 receptor, but not by the TrkA or TrkB receptors.