Neurodegeneration and prolonged immediate early gene expression throughout cortical areas of the rat brain following acute administration of MK801

DE OLMOS S, BENDER C, DE OLMOS JS, LORENZO A.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2009 vol. 164 p. 1347 - 1347

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none">N-methyl-D-aspartate receptor antagonist drugs (NMDA-A), such as dizocilpine (MK801), induce long-lasting behavioral disturbances reminiscent to psychotic disorders in humans. To identify cortical structures affected by NMDA-A, we used a single dose of MK801 (10 mg/kg) that caused low and high neurodegeneration in intact and orchiectomized male rats, respectively. Degenerating somas (neuronal death) and axona