Interleukin 10 and TNFalpha Synergistically Enhance The Expression of The G-Protein Coupled Formylpeptide Receptor 2 in Microglia

IRIBARREN P,; CHEN K,; GONG W,; CHO E,; LOCKETT S,; URANCHIMEG B,; WANG JM.

NEUROBIOLOGY OF DISEASE

Año: 2007 vol. 27 p. 90 - 90

0969-9961

p class="MsoBodyText" style="margin: 0cm 0cm 0pt;">Microglia are important participants in inflammatory responses in the central nervous system. We previously observed that tumor necrosis factor alpha (TNFa) induces the expression of the formylpeptide receptor mFPR2 on microglial cells. This chemoattractant receptor mediates microglial cell chemotaxis in response to a variety of peptides, including amyloid b peptide (Ab42), a major pathogenic factor in Alzheimer?s disease (AD). In search for agents that regulate microglial activation, we unexpectedly found that IL-10 enhanced the expre