Drug-Containing Layered Double Hydroxide/Alginate Dispersions for Tissue Engineering

ZANIN, JUAN PABLO; GERMAN A. GIL; GARCÍA, MÓNICA C.; ROJAS, RICARDO

ChemEngineering

MDPI

Lugar: Basel; Año: 2022 vol. 6

lginate (Alg) is increasingly studied as a constitutive material of scaffolds for tissue engineering because of its easy gelation and biocompatibility, and the incorporation of drugs into its formulation allows for its functionality to be extended. However, Alg presents a low cell adhesion and proliferation capacity, and the incorporation of drugs may further reduce its biocompatibility. Layered double hydroxides (LDH) are promising fillers for Alg-based biomaterials, as they increase cell adhesion and interaction and provide drug storage and controlled release. In this work, LDH containing ibuprofen or naproxen were synthesized by coprecipitation at a constant pH and their properties upon their incorporation in Alg dispersions (LDH-Drug/Alg) were explored. Drug release profiles in simulated body fluid and the proliferation of pre-osteoblastic MC3T3-E1 cells by LDH-Drug/Alg dispersions were then evaluated, leading to results that confirm their potential as biomaterials for tissue engi