Hippocampal CA1 Pyramidal Neurons of Mecp2 MutantMice Show a Dendritic Spine Phenotype Only in the Presymptomatic Stage

CHAPLEAU CA, BOGGIO ME, CALFA G, PERCY A, GIUSTETTO M, POZZO-MILLER L.

Neural Plasticity

Hindawi Publishing Corporation

Año: 2012 p. 1 - 1

1687-5443

!--[if gte mso 9]> Alterations in dendritic spines have been documented in numerous neurodevelopmental disorders, including Rett Syndrome (RTT). RTT, an X chromosome-linked disorder associated withmutations in MECP2, is the leading cause of intellectual disabilities in women. Neurons in Mecp2-deficient mice show lower dendritic sp