Resumen:
he current research studied the behavior adopted in the elevated plus
maze (EPM) of rats previously subjected to a social defeat using the
resident-intruder paradigm. One day after defeat, intruder animals
exhibited an anxiogenic-like behavior in the EPM. In addition, we also
evaluated the role of the corticosteroid receptor system
(minerlocorticoid - MR - and glucocorticoid - GR - receptors) from the
lateral septum (LS) on the anxiety generated by social defeat. The LS is
an area of the aversive circuitry that is preferentially activated in
passive defensive postures, and participates - together with other brain
areas - in the modulation of aversive states. Intruder animals were
infused into the LS with the MR or GR antagonist (ZK 91587 and RU 38486,
respectively) and then submitted to social stress. All rats were tested
in the EPM 1 day later. Only the administration of the GR antagonist,
but not the MR antagonist, into the LS normalized the anxiogenic
re