Artículos
Título:
Oral testosterone in male rats and the development of experimental autoimmune encephalomyelitis.
Autor/es:
MACCIÓ DR, CALFA G, ROTH GA
Referencias:
Año: 2005 vol. 12 p. 246 - 246
Resumen:
h4>OBJECTIVES:
Considering that sex steroids can influence the
immune system, we studied the development of experimental autoimmune
encephalomyelitis (EAE), a T-cell-mediated autoimmune disease of the
central nervous system, and the concomitant cell-mediated immunity in
gonadally intact and gonadectomized male Wistar rats given testosterone
supplementation.
METHODS/RESULTS:
Sham-operated rats and
surgically castrated animals were orally self-administered with vehicle
or testosterone added in the water bottle for 20 days before EAE
induction. The androgenic effect of oral testosterone
self-administration was evidenced by changes in body weight, and in the
weights of androgen-dependent testes and seminal vesicles. Testosterone
administration reduced the incidence of clinical signs of EAE in
sham-operated animals and reversed the clinical symptoms of the disease
associated with castrated EAE animals. The clinical signs observed in