A BDNF sensitive mechanism is involved in the fear memory resulting from the interaction between stress and the retrieval of an established trace

GIACHERO M, BUSTOS SG, CALFA G, MOLINA V

COLD SPRING HARBOR LAB PRESS

Año: 2013 p. 245 - 245

he present study investigates the fear memory resulting from the interaction of a stressful experience and the retrieval ofan established fear memory trace. Such a combination enhanced both fear expression and fear retention in adult Wistar rats.Likewise, midazolam intra-basolateral amygdala (BLA) infusion prior to stress attenuated the enhancement of fear memorythus suggesting the involvement of a stress-induced reduction of the GABAergic transmission in BLA in the stress-inducedenhancing effect. It has been suggested that, unlike the immediate-early gene Zif268 which is related to the reconsolidationprocess, the expression of hippocampal brain-derived neurotrophic factor (BDNF) is highly correlated with consolidation.We therefore evaluate the relative contribution of these two neurobiological processes to the fear memory resulting fromthe above-mentioned interaction. Intra-dorsal hippocampus (DH) infusions of either the antisense Zif268 or t