Dorsolateral Entorhinal Cortex in the destabilization/reconsolidation Process of Fear Memories.

RAMIRO GABRIEL COMAS MUTIS AND GASTÓN DIEGO CALFA.

Congreso; XXXVI Congreso anual de la Sociedad Argentina de Investigación en Neurociencias.; 2021

The Dorsal Hippocampus (DH) and the basolateral complex of the Amygdala (BLA) are brainstructures critically involved in the destabilization/reconsolidation process. Interestingly, BLAexerts a modulatory role over the structural plasticity of DH during said process. However,there is no direct connection between the two structures. The entorhinal cortex, particularlythe dorsolateral region (dl-CEnt) is a parahippocampal structure regarded as the main input of the Hippocampus, and potentially an operational intermediate for the emotional information between both brain areas.It the present work we explored the role of the dl-CEnt, trough pharmacological manipulation, in the destabilization/reconsolidation of fear memories as a step in outlining and further understanding the neural circuit between BLA and DH.