A hiperexcited state of the basolateral amygdala complex influences the changes in hippocampal structural plasticity associated with the fear memory destabilization/reconsolidation process.

SOSA M CANDELA; COMAS MUTIS RG; RIVA GARGIULO M; BENDER, C.L.; CALFA GD

Congreso; XXXVIII Congreso anual de la Sociedad Argentina de Investigación en Neurociencias; 2023

The occurrence of the destabilization/reconsolidation process of a fear memory plays a pivotal role in the appearance of some symptoms of PTSD and other anxiety disorders. It is known that the basolateral complex of the amygdala (BLA) is a key area modulating such clinical manifestations. Interestingly, a hiperexcitability of this area was observed concomitantly with the stress exposure and with changes in the dynamisms of hippocampal structural plasticity.In this work we seek to observe and reverse the impairment of the structural plasticity of dorsal hippocampus due to a pharmacological hyperexcited state in the BLA that emulates the behavioral and structural manifestations of the stress prior to conditioning fear memory. Subsequently, intraperitoneal d-cycloserine (partial NMDA receptor agonist) was used prior to memory recall to reverse the behavioral and synaptic impairment.