Effect of Escitalopram on fear memory reconsolidation in male mice

MATEOS CARLOS A; GIACHERO, MARCELO; CALFA, G.D.; WEISSTAUB NOELIA; BEKINSCHTEIN PEDRO

Congreso; XXXVII Congreso anual de la Sociedad Argentina de Investigación en Neurociencias; 2022

The retrieval of a stored fear memory can make it transiently vulnerable to interference by pharmacological agents. Previous experiments demonstrated that a single fluoxetine (FLX) 10 mg/kg dose can disrupt contextual fear memory reconsolidation in mice. Here we evaluated the effect of another antidepressant approved for human use, escitalopram (eCIT), on contextual fear memory reconsolidation in male mice. After 5 minute exposure to the training context, eCIT (1, 5 or 10 mg/kg) or vehicle (VEH) (n=7-11 mice per group) were I.P. administrated. Two and fourteen days later, freezing response was scored when mice were re-exposed to the training environment (Test 1 and 2).A two-way repeated measures ANOVA analysis did not reveal a significant interaction between groups and the experimental phase. Only LSD post hoc test showed mean differences between reactivation and Test 2 in eCIT 5 mg/kg and eCIT 10 mg/kg treatment groups.This results showed that eCIT 1, 5 or 10 mg/kg do not have the same effect as FLX 10 mg/kg in disrupting contextual fear memory reconsolidation in male mice.