Involvement of membrane tubulin in erythrocyte deformability and blood pressure

AMAIDEN, M.R.; MONESTEROLO, N.E.; SANTANDER, V.S.; CAMPETELLI, A.N.; ARCE, C.A.; PIE, J.; HOPE, S.I.; VATTA, M.S.; CASALE, C.H.

LIPPINCOTT WILLIAMS & WILKINS

Lugar: Philadelphia; Año: 2012 vol. 30 p. 1414 - 1414

bjective: To test the hypothesis that erythrocyte deformability is influenced by changes in the content of membrane tubulin (Mem-tub). Methods and results: Human erythrocytes contain tubulin distributed in three pools (membrane, sedimentable, soluble). Erythrocytes from hypertensive humans have a higher proportion of Mem-tub. Increased Mem-tub content in hypertensive patients was correlated with decreased erythrocyte deformability. Treatment of erythrocytes from normotensive individuals with taxol increased Mem-tub content and reduced deformability, whereas treatment of hypertensive patients erythrocytes with nocodazole had the opposite effect. In-vivo experiments with rats were performed to examine the possible relationship between Mem-tub content, erythrocyte deformability, and blood pressure. Spontaneously hypertensive rats (SHRs) showed lower erythrocyte deformability than normotensive Wistar rats. During the development of hypertension in SHR, tubulin in erythr