Regulation of acetylated tubulin/Na,K-ATPase interaction by L-glutamate in non-neural cells: involvement of microtubules.

CASALE, C.H; PREVITALI, G.; SERAFINO, J.J; CARLOS ANGEL ARCE; BARRA, H.S

ELSEVIER SCIENCE BV

Año: 2005 vol. 1721 p. 185 - 185

font face="AdvTT5843c571" size="1"> A subpopulation of membrane tubulin consisting mainly of the acetylated isotype is associated with Na+,K+-ATPase and inhibits the enzyme activity. We found recently that treatment of cultured astrocytes with l-glutamate induces dissociation of the acetylated tubulin/ Na+,K+-ATPase complex, resulting in increased enzyme activity. We now report occurrence of this phenomenon in non-neural cells. As in the case of astrocytes, the effect of l