Suppression of acute Experimental allergic encephalomyelitis by intraperitoneal administration of synaptosomal antigens

ALICIA L. DEGANO; ANA E. BUCHER; GERMAN A. ROTH

JOURNAL OF NEUROSCIENCE RESEARCH

Wiley-Liss

Año: 1998 vol. 53 p. 187 - 187

0360-4012

b> The effect of a synaptosomal fraction isolated from bovine brain was examined on acute experimental allergic encephalomyelitis (EAE) inWistar rats. Intraperitoneal administration of the animals with low doses of saline-soluble synaptosomal antigens 10 and 3 days previous to the active induction of the disease was an effective way of suppressing EAE. This treatment diminished the incidence and severity of EAE, reverted the appearance of central nervous system histological and biochemical alterations, and produced changes in the autoimmune humoral response against the encephalitogenic myelin basic protein. The phenomenon observed by treatment with synaptosomal fraction is similar to the previously described suppression mediated by myelin antigens. Taking into account that affinity-purified antibodies and T  lymphocytes specific for myelin basic protein can also recognize several neuronal proteins, among them the specific syn