Passive transfer of Experimental autoimmune encephalomyelitis in Wistar rats

ALICIA L. DEGANO; GERMAN A. ROTH

Wiley-Liss

Año: 2000 vol. 59 p. 283 - 283

font size="2" face="HelveticaNeue-Roman"> We have used passive transfer of myelin-reactive lymphocytes in the Wistar rat model of experimental autoimmune encephalomyelitis (EAE) to investigate the nature of the central nervous system immunopathological alterations induced by these cells. Mononuclear cells from lymph nodes or spleen from sick myelin/complete Freund?s adjuvant-immunized donors did not transfer clinical disease. However, depending on the previous treatment of the transferred cells, recipients develop central nervous system biochemical and histological alterations. Fresh cells from lymph nodes immediately transferred after procurement from the sick EAE donor rat were capable of inducing the most significant diminution in the content of myelin basic protein, sulfatides, and 29,39