Mannan from Aloe saponaria inhibits tumoral cell activation and proliferation

M CECILIA SAMPEDRO; RODOLFO L. ARTOLA; MARIANO MURATURE; DOMINGO MURATURE; YANINA DITAMO; GERMAN A. ROTH; SILVIA KIVATINITZ

Elsevier

Año: 2004 vol. 4 p. 411 - 411

p style="LINE-HEIGHT: normal; MARGIN: 0cm 0cm 10pt; mso-margin-top-alt: auto; mso-margin-bottom-alt: auto; mso-outline-level: 2" class="MsoNormal">In this study, we tested the antiproliferative effects of mannan from Aloe saponaria using normal murine (SpMC) and human cells (PBMC) and several tumoral cell lines. Employing flow cytometry, it could be determined that mannan inhibits the proliferative response in normal and tumoral cells. Mannan affects the expression of CD3(+) SpMC indicating that mannan inhibits mainly T lymphocyte proliferative response. Also in SpMC cultured with or without mitogen mannan produces an increase of an activation marker (CD25). On C1498 cell line, mannan reduces CD3 expression and abolishes the CD25 expression. In conclusion, m