Neuroprotective effect of a synapsin peptide genetically fused to the B subunit of Escherichia coli heat-labile enterotoxin in rat autoimmune encephalomyelitis

M. JULIA SCERBO; LUCÍA L. RUPIL; MARIO J. BIBOLINI; GERMAN A. ROTH; CLARA G. MONFERRAN

Wiley-Liss

Año: 2009 vol. 87 p. 2273 - 2273

p style="LINE-HEIGHT: 200%; MARGIN: 0cm 0cm 0pt; tab-stops: 21.3pt" class="MsoNormal">       Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antigens could suppress EAE. Herei