Effect of diphenyl diselenide on the development of experimental autoimmune encephalomyelitis

CHANADAY RICAGNI NATALÍ L.; FABRO DE BEM ANDREZA; ROTH GERMAN A.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2011 vol. 59 p. 1155 - 1155

xperimental autoimmune encephalomyelitis (EAE) is a T cell-mediated inflammatory and demyelinating disease of the central nervous system with clinical and pathological similarities with multiple sclerosis. The oxidative stress is one of the major mediators of demyelination and axonal damage in both, multiple sclerosis and EAE. Therefore, several studies are being performed to assess whether treatment with antioxidants prevents the progression of these diseases. Some organic forms of selenium that exhibit glutathione peroxidase-like activity have become good candidates for disease prevention and therapy since they catalytically remove oxidative stressors. Particularly, diphenyl diselenide ((PhSe)2) exerts antioxidant activity and has neuroprotective effects in several systems. The aim of the present study was to prove the therapeutic activity of (PhSe)2 on the development of EAE. Intraperitoneally administered (PhSe)2 (1–25 lmoles/kg body weight/day) reduced the incidence of the dis