Diphenyl diselenide-modulation of macrophage activation: downregulation of classical and alternative activation markers

RUPIL LUCÍA L.; DE BEM ANDREZA F.; ROTH GERMAN A.

SAGE PUBLICATIONS LTD

Año: 2012 vol. 18 p. 627 - 627

iphenyl diselenide ((PhSe)2), a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. As macrophages respond to microenvironmental stimuli and can display activities engaged in the initiation and the resolution of inflammation, in the present report we describe the ability of (PhSe)2 to modulate the macrophage activation. Our data indicate that (PhSe)2 could inhibit the NO production in a dose-dependent fashion in peritoneal macrophages activated by LPS or treated with vehicle alone. We could demonstrate that this effect correlated with a reduction in the expression of the inducible NO synthase in (PhSe)2-treated cells. Furthermore, (PhSe)2 suppressed the production of reactive oxygen species, diminished the activity of the arginase enzyme, and the accumulation of nitrotyrosine modified proteins in LPS-stimulated macrophages. This compound also diminished the antigen presentation capacity of classically activated macrophage