Participation of central and peripheral benzodiazepine receptors in the modulatory effect of diazepam on experimental autoimmune encephalomyelitis

FERNÁNDEZ HURST, NICOLÁS; ZANETTI SAMANTA R.; BÁEZ, NATALIA S.; BIBOLINI MARIO J.; BOUZAT CECILIA B.; ROTH GERMAN A.

JOURNAL OF NEUROIMMUNOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2017 vol. 313 p. 145 - 145

0165-5728

enzodiazepines are psychoactive drugs and some of them have also effects on immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development by decreasing the incidence of the disease, reducing the number of inflammatory cells in CNS and preventing the increase in TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.