Play behavior and stress responsivity in periadolescent offspring exposed prenatally to cocaine

WOOD,R.D.; MOLINA VICTOR ALEJANDRO; WAHNER, J.M.; SPEAR, L.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1995 vol. 52 p. 367 - 367

lay behavior and stress responsiveness were examined in offspring exposed gestationally to cocaine. The subjects were offspring of Sprague-Dawley rat dams given SC injections of 40 mg/kg/3 cc cocaine HCl daily from gestational days 8-20 (C40), pair-fed dams injected daily with saline (PF), and untreated control darns (LC). Peliadolescent (postnatal day (P) 30-36) male and female rats were assigned to either pretest Stress or No Stress conditions. Every other day Stress animals were exposed to a stresser (on P30-foot shock; P32-white noise; P34-forced swim; P36-foot shock), with each stresser being administered 4 h prior to a play session. Immobility during one of the stressors, foot shock, was used to assess stress responsiveness. Play sessions consisted of pairing each experimental animal with a same-sex, nonexperimentally manipulated conspecific for 7 min. The results indicated that periadolescent offspring exposed gestationally to cocaine differed from controls in their stress resp