Gangliosides facilitate the recovery of behavioral response mediated by dopaminergic sites following their irreversible blockade

KELLER, E.; MOLINA VICTOR ALEJANDRO

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1993 vol. 31 p. 161 - 161

p class="marginB3" align="justify">The effect of acute and chronic exogenous ganglioside (G) administration on the functional recovery of dopaminergic receptors following their blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) was investigated by means of apomorphine (APO)-induced stereotyped behavior. Animals previously treated with EEDQ exhibited a lack of behavioral response to APO 6 or 24 h later. A progressive behavioral recovery was already evident at day 3 and reached control values at day 7. G pretreatment accelerated the behavioral recovery after EEDQ administration, because a higher behavioral response to APO in these animals as compared with rats treated with EEDQ alone at the same time was observed. These findings indicate that G accelerates the functional recovery of dopaminergic sites following their irreversible blockade.