Adrenocorticotrophic hormone influences the development of adaptive changes on dopamine autoreceptors induced by chronic administration of desipramine

VOLOSIN, M.; CANCELA, L.M.; LAINO, C.; MASSEI, M.; MOLINA VICTOR ALEJANDRO

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1991 vol. 30 p. 719 - 719

p class="marginB3" align="justify">The influence of adrenocorticotropic hormone (ACTH) in the adaptive changes on central dopamine (DA) autoreceptors following chronic administration of desipramine (DMI) has been examined in rats. Dopamine had an inhibitory effect on basal and K+-induced release of [3H]DA from slices of striatum and n. accumbens of rats treated chronically (10 days) with ACTH (50 IU/kg, s.c.), DMI (10 mg/kg, i.p.) or the combination of ACTH and DMI. In slices of n. accumbens, but not in slices of striatum of rats exposed to the combined treatment of ACTH and DMI, a significant decrease in the inhibitory effect of exogenous DA on stimulated release of [3H]DA was observed. Chronic administration of ACTH or DMI alone had no effect. The effect of the combined treatment with both agents, on the reactivity of these DA receptors was evaluated by means of apomorphine-induced hypoactivity. The administration of ACTH and DMI (5 mg/kg, i.p.) redu