Ganglioside enhance the anti immobility response elicited by several antidepressant treatments in mice

CORDOBA, N; BASSO, A.M.; MOLINA VICTOR ALEJANDRO; ORSINGHER,O.

SPRINGER

Lugar: Berlin; Año: 1990 vol. 100 p. 555 - 555

p class="marginB3" align="justify">Ganglioside pretreatment enhanced the anti-immobility effect induced in the forced swim test after a chronic treatment with desipramine, mianserin, clomipramine, nialamide or repeated electroconvulsive shock in mice. Gangliosides, which had no effect per se, showed a clear dose-response relationship in enhancing the anti-immobility effect of desipramine. These results suggest that, regardless of their mechanisms of action, gangliosides facilitate the behavioral response of several antidepressant treatments.