Gangliosides enhance behavioral and neurochemical effects induced by chronic desipramine (DMI) treatment

MOLINA VICTOR ALEJANDRO; KELLER, E.; ORSINGHER,O.

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1989 vol. 160 p. 247 - 247

p class="marginB3" align="justify">Rats pretreated with gangliosides showed a significant enhancement of the anti-immobility effect of desipramine (DMI) in the forced swimming test. Accordingly, an associated treatment of gangliosides and DMI for 7 days significantly enhanced â-adrenergic down-regulation in the frontal cortex as compared with the effect of DMI alone. Gangliosides exerted an accelerating effect on the decrease of â-adrenoceptor density induced by DMI, since the down-regulation phenomenon appeared after 3 days of treatment. Gangliosides did not affect the pharmacokinetics of DMI, since associated acute or prolonged treatments did not modify the brain levels of DMI as compared to the levels of animals that had received DMI alone. These results showed a stimulating effect on gangliosides on the development of adaptative receptor changes induced by chronic DMI treatment.