Reduced antiimmobility effect of repeated desipramine (DMI) treatment in adult rats undernourished at perinatal age.

MOLINA VICTOR ALEJANDRO; KELLER, E.; ORSINGHER,O.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1987 vol. 26 p. 417 - 417

p class="marginB3" align="justify">Adult rats submitted to a protein deprivation schedule at perinatal age showed a reduced anti-immobility effect following seven days of DMI treatment (20 mg/kg/day) in the forced swimming test. The ineffectiveness of DMI treatment is attributed to the inability of deprived animals to produce neuronal adaptative changes in central monoaminergic pathways.