Inhibition of catecholamine biosynthesis inhibition and memory processes

FULGINITI, S.; MOLINA VICTOR ALEJANDRO; ORSINGHER,O.

SPRINGER

Lugar: Berlin; Año: 1976 vol. 51 p. 65 - 65

p class="marginB3" align="justify">Rats injected with 60 mg/kg of á methyl tyrosine (á MT immediately after a training in a shuttle box impaired retention of conditioned avoidance response (CAR). DL Dopa (200 mg/kg) administered 5, 30, 60, and 120 min after á MT treatment counteracted the depressive effect of this drug during the retention test; at longer times it was ineffective. Post trial injections of 600 mg/kg of diethyldithiocarbamate (DDC) impaired retention of CAR; at a lower dose (300 mg/kg) it had no effect. Administration of á MT (60 mg/kg) immediately after passive avoidance training lowered memory in females but not in males. These results suggest that noradrenaline (NA) is required for memory consolidation processes for about 2 h after training.