Alterations of serotonin neurotransmission and inhibition of mouse killing behavior: II Effects of selective and reversible monoamine oxidase inhibitors of type A.

ISEL, F.; CIESIELSKI, L.; GOBAILLE, S.; MOLINA VICTOR ALEJANDRO; MANDEL, P.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1988 vol. 29 p. 97 - 97

hree groups of rats were tested for mouse killing behavior after IP injection of selective and reversible type A monoamine oxidase inhibitors. The rats were either spontaneous killers, or non-killers which acquired killing behavior following para-chlorophenylalanine treatment or electrolytical destruction of dorsal and median raphe nuclei. Moclobemide (para-chloro-N-(2-morpholinoethyl)-benzamide), cimoxatone (3-(4-(3-cyanophenyl-methoxy)phenyl)-5-(methoxy) -2-oxazolidinone, MD 780515), toloxatone (5-(hydroxymethyl)- 3-(3-methylphenyl)-2-oxazolidinone) and amiflamine ((+)-4-dimethylamino-2, alpha-dimethylphenethyl amine, FLA 336 (+)) were used as selective and reversible monoamine oxidase inhibitors of type A. Cimoxatone, toloxatone and amiflamine inhibited mouse killing behavior of spontaneous killer rats without apparent sedation, whereas moclobemide was not efficient at doses which did not decrease locomotor activity. A similar inhibition of mouse killing behavior was obtained in sp