Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse killing behavior

MOLINA VICTOR ALEJANDRO; CIESIELSKI, L.; GOBAILLE, S.; MANDEL, P.

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1986 vol. 24 p. 657 - 657

ntra olfactory bulb administration of three classes of GABA-mimetics (GABAa agonists, inhibitors of reuptake, inhibitors of GABA degradation) clearly inhibit mouse-killing behavior, without sedation. A linear correlation is observed between GABA levels increase in the olfactory bulbs and muricidal inhibition following local injection of valproic acid and gamma-vinyl GABA, two GABA-T inhibitors; the differences observed between these two compounds may be due to the differences in their mechanism of action on GABA-T activity and to the different pool of GABA on which they act. No diffusion to extra bulbar sites were observed after local administration of gamma-vinyl GABA. This evidence suggests an inhibitory role of GABA from olfactory bulbs in the modulation of mouse-killing behavior