Artículos
Título:
Erk activation in the amygdala and hippocampus induced by fear conditioning in ethanol withdrawn rats: Modulation by mk-801
Autor/es:
BERTOTTO, M. EUGENIA; MALDONADO, N.; BIGNANTE, A.; GOROSITO, S.; CAMBIASSO, MARÍA J. MOLINA, VICTOR A. AND MARTIJENA, IRENE D
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2011 vol. 21 p. 892 - 892
Resumen:
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The extracellular signal-regulated kinase (ERK) pathway, which can be activated by NMDA receptor
stimulation, is involved in fear conditioning and drug addiction. We have previously shown that
withdrawal from chronic ethanol administration facilitated the formation of contextual fear
memory. In order to explore the neural substrates and the potential mechanism involved in this
effect, we examined: 1) the ERK1/2 activation in the central (CeA) and basolateral (BLA) nuclei of
the amygdala and in the dorsal hippocampus (dHip), 2) the effect of the NMDA receptor antagonist
MK-801 on fear conditioning and ERK activation and 3) the effect of the infusion of U0126, a MEK
inhibitor, into the BLA on fear memory formation in ethanol withdrawn rats.Rats made depen