Stress response recruits the hippocampal endocannabinoid system for the modulation of fear memory.

LUCAS DE OLIVEIRA ALVARES, DOUGLAS SENNA ENGELKE, FELIPE DIEHL, RÓBSON SHEFFER-TEIXEIRA, JOSUÉ HAUBRICH, LINDSEY DE FREITAS CASSINI, VICTOR ALEJANDRO MOLINA AND JORGE A. QUILLFELDT

COLD SPRING HARBOR LAB PRESS

Lugar: New York; Año: 2010 vol. 17 p. 202 - 202

font color="#231f20" size="1" face="AdvTTcc51cd19"> The modulation of memory processes is one of the several functions of the endocannabinoid system (ECS) in the brain, with CB1 receptors highly expressed in areas such as the dorsal hippocampus. Experimental evidence suggested an important role of the ECS in aversively motivated memories. Similarly, glucocorticoids released in response to stress exposure also modulates memory formation, and both stress and dexamethasone activate the ECS. Here, we investigate the interaction between the ECS and glucocorticoids in the hippocampus in the modulation of fear memory consolidation. Two protocols with different shock intensities were used in order to control the level of aversiveness. Local infusion of AM251 into the