Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction.

LUCAS DE OLIVEIRA ALVARES; BRUNA P GENRO; FELIPE DIEHL, M.; VICTOR A MOLINA; JORGE A QUILLFELDT

Elsevier Science

Año: 2008 vol. 154 p. 1648 - 1648

b> Retrieval of a consolidated memory triggers a number of processes which depend, among other factors, on the duration of the reactivation session: reconsolidation requires a brief reactivation session, and extinction, a prolonged one. The scope of this study is to explore the potential role of the hippocampal endocannabinoid system on reconsolidation and extinction processes. Bilateral infusion of the CB1 cannabinoid receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)- 4-methyl-1H-pyrazole-3-carboxamide (AM251) into the CA1 region of the dorsal hippocampus of Wistar rats after memory reactivation facilitated the reconsolidation of the contextual fear conditioning memory. The i