Ganglioside attenuate stress-induced changes on body weight, motor activity and on the behavioral response to 5-methoxy-N,N-dimetyltryptamine

CANCELA, L.M.; VOLOSIN, M.; MOLINA VICTOR ALEJANDRO

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1996 vol. 40 p. 105 - 105

he major goal of this study was to evaluate the influence of gangliosides (GANG) treatment on the onset of adaptive changes and the sequelae induced by stress exposure. With this purpose, the behavioral response to 5-metoxy-N,N- dimethyltryptamine (5-MeODMT, 5 mg/kg, IP) and motor activity were evaluated in rats previously submitted either to a single restraint session (2 h) or to a daily restraint event for 3 consecutive days, combined or not to GANG administration (30 mg/kg IP). GANG was always injected 2 h before stress exposure. In addition, differences in body weights were recorded throughout the experiments. A similar behavioral response after 5-MeODMT was observed between saline (SAL) and GANG unstressed rats. Exposure to one or three restraint sessions did not modify the behavioral response to 5-MeODMT, whereas the association of GANG and stress during 3 consecutive days enhanced forepaw treading and hindlimb abduction. SAL-treated animals submitted to a single or to three str