ACTH accelerates the attenuation of Alpha2 adrenoceptors response in nucleus accumbens following chronic desipramine

VOLOSIN, M.; CANCELA, L.M.; MOLINA VICTOR ALEJANDRO

PROUS SCIENCE

Año: 1992 vol. 14 p. 189 - 189

p class="marginB3" align="justify">The inclusion of clonidine (CLO) induced a dose-dependent reduction of K+-evoked [3H] dopamine ([3H]DA) release in slices from rat nucleus accumbens. This inhibition was clearly attenuated in animals previously administered desipramine daily (DMI, 10 mg/kg i.p.) during 21 days, but not in rats submitted to a persistent treatment with DMI during 10 days. However, the coadministration of adrenocorticotrophic hormone (ACTH, 50 IU/kg s.c.) and DMI (10 mg/kg i.p.) for 10 days provoked a clear decrease in the inhibition produced by á2-adrenoceptor stimulation, while ACTH alone had no effect. These results nay indicate that ACTH accelerates the onset of DMI-induced adaptive changes on central á2-adrenoceptor in the mesolimbic area.