Antidepressants reduce inactivity during both inescapable shock administration and shuttle box testing

MURUA, S.; MOLINA VICTOR ALEJANDRO

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1991 vol. 204 p. 187 - 187

p class="marginB3" align="justify">The occurrence of inactivity during inescapable shock is a good predictor of escape deficit because a positive correlation was obtained between the two factors. Chronic desipramine (DMI) administration prior to inescapable shock clearly reduced the inactivity during this aversive experience. Moreover, repeated DMI administration either before or after inescapable shock reversed the increase, in escape failures and in inactivity during shuttle-box testing produced by this inescapable shock. A single injection with DMI before either inescapable shock or shuttle-box test altered neither in activity nor escape deficit. Clomipramine and phenelzine were also effective to reduce inactivity and escape failures. However, other drugs without antidepressant properties, such as haloperidol, amphetamine, and diazepam reduced neither inactivity nor escape deficit. These data suggest that an anti-inactivity effect is critically involved in the reversal of inescapab