Shuttle box deficits induced by chronic variable stress: reversal by imipramine administration

MURUA, S.; GOMEZ, R.; ANDREA, M.; MOLINA VICTOR ALEJANDRO

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1991 vol. 38 p. 125 - 125

p class="marginB3" align="justify">Escape performance in a shuttle-box task was evaluated in rats chronically exposed to a series of unpredictable stressors either during 14 or 7 consecutive days. Failure in escape responses was observed when animals were subjected to both regimens of variable aversive situations. The association between chronic exposure to unpredictable stressors with imipramine resulted in a significant reversal of escape deficits. Furthermore, animals submitted to repeated immobilization sessions during 7 days presented similar escape response to control rats. A possible involvement of beta-adrenergic sites on this behavioral response is discussed.